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\u82f1\u6587\u540d\u79f0\uff1aTeruravone<\/p>\r\n\r\n\r\n\r\n
\u7814\u7a76\u4ee3\u53f7\uff1aTR<\/p>\r\n\r\n\r\n\r\n
\u5242\u578b\uff1a\u51bb\u5e72\u7c89\u9488\u3002<\/p>\r\n\r\n\r\n\r\n
\u89c4\u683c\uff1a15mg<\/p>\r\n\r\n\r\n\r\n
\u6ce8\u518c\u5206\u7c7b\uff1a\u5316\u5b66\u836f1\u7c7b<\/p>\r\n\r\n\r\n\r\n
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\u4e13\u5229\u7b49\u77e5\u8bc6\u4ea7\u6743\u4fdd\u62a4\u60c5\u51b5\uff1aZL200910129816.3<\/p>\r\n\r\n\r\n\r\n
\u4e34\u5e8a\u6279\u4ef6\uff1a2017L04386\uff1b2017L04387<\/p>\r\n\r\n\r\n\r\n
\u7814\u7a76\u8fdb\u5c55\uff1a I\u671f\u4e34\u5e8a\u7814\u7a76<\/p>\r\n\r\n\r\n\r\n
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1<\/strong>\u3001\u6d41\u884c\u75c5\u5b66<\/strong><\/p>\r\n\r\n\r\n\r\n \u6025\u6027\u8111\u5352\u4e2d\u662f\u4e34\u5e8a\u591a\u53d1\u75c5\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u81f4\u6b7b\u7387\u3001 \u81f4\u6b8b\u7387\uff0c\u5c45\u6240\u6709\u75be\u75c5\u81f4\u6b8b\u7387\u9996\u4f4d\uff0c\u4e25\u91cd\u5371\u5bb3\u4eba\u7c7b\u5065\u5eb7\u3002\u8111\u5352\u4e2d\u540e\u9057\u75c7\u4e3a\u4e0d\u540c\u7a0b\u5ea6\u7684\u80a2\u4f53\u529f\u80fd\u969c\u788d\u548c\u8bed\u8a00\u969c\u788d\uff0c\u8111\u5352\u4e2d\u540e\u5f80\u5f80\u5408\u5e76\u4e00\u4e9b\u5e76\u53d1\u75c7\uff0c\u5982\u8ba4\u77e5\u969c\u788d\u3001\u766b\u75eb\u3001\u6291\u90c1\u7b49\u3002\u56e0\u6b64\uff0c\u6025\u6027\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u7ed9\u793e\u4f1a\u548c\u5bb6\u5ead\u5e26\u6765\u6c89\u91cd\u8d1f\u62c5\u3002<\/p>\r\n\r\n\r\n\r\n 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2<\/strong>\u3001\u9002\u5e94\u75c7\u7684\u6cbb\u7597\u73b0\u72b6\u548c\u5e38\u7528\u836f\u7269<\/strong><\/p>\r\n\r\n\r\n\r\n \u8111\u5352\u4e2d\u75c7\u72b6\u5305\u62ec\u7a81\u7136\u9ebb\u6728\u6216\u65e0\u529b\uff0c\u7279\u522b\u662f\u4e00\u4fa7\u80a2\u4f53\u9ebb\u6728\u3001\u65e0\u529b\uff1b\u7a81\u7136\u610f\u8bc6\u6df7\u4e71\u6216\u8a00\u8bed\u4e0d\u6e05\u3001\u7406\u89e3\u529b\u969c\u788d\uff1b\u7a81\u7136\u51fa\u73b0\u4e00\u773c\u6216\u53cc\u773c\u89c6\u529b\u969c\u788d\uff1b\u7a81\u7136\u4e0d\u80fd\u884c\u8d70\uff0c\u5934\u6655\uff0c\u5e73\u8861\u6216\u534f\u8c03\u4e27\u5931\uff1b\u65e0\u539f\u56e0\u7684\u7a81\u7136\u4e25\u91cd\u5934\u75db\u3001\u5455\u5410\u3001\u660f\u8ff7\u7b49\u5168\u8111\u75c7\u72b6\u3002<\/p>\r\n\r\n\r\n\r\n 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\u6c27\u81ea\u7531\u57fa\u4ecb\u5bfc\u7684\u81ea\u7531\u57fa\u8fde\u9501\u53cd\u5e94\u662f\u6025\u6027\u8111\u6897\u6b7b\u795e\u7ecf\u635f\u4f24\u5c24\u5176\u662f\u8fdf\u53d1\u795e\u7ecf\u5143\u635f\u4f24\u7684\u91cd\u8981\u539f\u56e0\u3002\u81ea\u7531\u57fa\u7684\u4ea7\u751f\u9014\u5f84\u5305\u62ec\uff1a(1) \u7f3a\u8840\u540e\u9ec4\u560c\u5464\u6c27\u5316\u9176\u5f62\u6210\u589e\u52a0\uff0c\u5728\u50ac\u5316\u6b21\u9ec4\u560c\u5464\u8f6c\u53d8\u4e3a\u9ec4\u560c\u5464\u5e76\u8fdb\u800c\u8f6c\u53d8\u4e3a\u5c3f\u9178\u7684\u8fc7\u7a0b\u4e2d\u91ca\u653e\u5927\u91cf\u7535\u5b50\uff0c\u5e76\u4e3a\u5206\u5b50\u6c27\u6240\u63a5\u53d7\uff0c\u4ea7\u751f\u8d85\u6c27\u9634\u79bb\u5b50\u81ea\u7531\u57fa\uff0c\u540e\u8005\u5728\u9499\u79bb\u5b50\u7684\u53c2\u4e0e\u4e0b\u5f62\u6210\u66f4\u4e3a\u6d3b\u8dc3\u7684\u7f9f\u6c27\u81ea\u7531\u57fa\uff1b(2) \u4e2d\u6027\u7c92\u7ec6\u80de\u6fc0\u6d3b\u4ea7\u751f\u5927\u91cf\u81ea\u7531\u57fa\uff1b(3) \u7ebf\u7c92\u4f53\u635f\u4f24\u5bfc\u81f4\u7ec6\u80de\u8272\u7d20\u6c27\u5316\u9176\u7cfb\u7edf\u529f\u80fd\u7d0a\u4e71\uff0c\u4ea7\u751f\u6c27\u81ea\u7531\u57fa\uff1b(4) \u513f\u8336\u915a\u80fa\u7684\u81ea\u8eab\u6c27\u5316\u53ef\u4ea7\u751f\u6c27\u81ea\u7531\u57fa\u3002<\/p>\r\n\r\n\r\n\r\n Coppieters\u7b49\u5229\u7528\u6b63\u7535\u5b50\u53d1\u5c04\u578b\u8ba1\u7b97\u673a\u65ad\u5c42\u663e\u50cf\u6280\u672f(PET)\u7814\u7a76\u663e\u793a\uff0c\u8111\u635f\u4f24\u540e\uff0c\u8111\u4ee3\u8c22\u72b6\u51b5\u4e0d\u826f\u73b0\u8c61\u53ef\u6301\u7eed14\u5929\u4e4b\u4e45\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u5931\u53bb\u6eb6\u6813\u673a\u4f1a\u7684\u8111\u6897\u6b7b\u60a3\u8005\uff0c\u5176\u5c40\u90e8\u7f3a\u8840\u7ec4\u7ec7\u5c06\u906d\u53d7\u6301\u7eed7\uff5e14\u5929\u7684\u4ee3\u8c22\u969c\u788d\u548c\u518d\u704c\u6ce8\u635f\u4f24\u3002\u7136\u800c\uff0c\u5728\u8fd9\u79cd\u635f\u4f24\u7684\u540c\u65f6\uff0c\u7ef4\u6301\u8db3\u591f\u7684\u5e73\u5747\u52a8\u8109\u538b\u53ef\u4f7f\u7ec4\u7ec7\u5145\u5206\u704c\u6d41\uff0c\u6539\u5584\u5fae\u5faa\u73af\u5e76\u5c3d\u5feb\u6d88\u9664\u518d\u704c\u6ce8\u635f\u4f24\u7684\u6bd2\u6027\u4f5c\u7528\u3002\u4e0a\u8ff0\u7814\u7a76\u7ed3\u679c\u4e3a\u4e34\u5e8a\u63d0\u4f9b\u4e86\u5352\u4e2d\u6025\u6027\u671f\u795e\u7ecf\u4fdd\u62a4\u6027\u6cbb\u759714\u5929\u7684\u7406\u8bba\u4f9d\u636e\u3002<\/p>\r\n\r\n\r\n\r\n \u8111\u6897\u585e\u7531\u4e8e\u8111\u8840\u4f9b\u969c\u788d\uff0c\u9020\u6210\u795e\u7ecf\u7ec6\u80de\u529f\u80fd\u4e27\u5931\u800c\u5f15\u8d77\u7684\u4e00\u7cfb\u5217\u795e\u7ecf\u7cfb\u7edf\u529f\u80fd\u969c\u788d\u6027\u75be\u75c5\u3002\u5bf9\u8111\u6897\u585e\u7684\u6cbb\u7597\uff0c\u8fc5\u901f\u590d\u6d41\u518d\u901a\u662f\u8111\u6897\u585e\u6025\u6027\u671f\u6cbb\u7597\u6210\u529f\u7684\u524d\u63d0\uff0c\u800c\u5ef6\u957f\u8111\u7ec6\u80de\u8010\u53d7\u7f3a\u6c27\u7684\u65f6\u95f4\u548c\u52a0\u5f3a\u590d\u6d41\u518d\u901a\u540e\u590d\u6742\u7684\u75c5\u7406\u751f\u7406\u8fc7\u7a0b\u4e2d\u7684\u751f\u5b58\u80fd\u529b\uff0c\u662f\u6cbb\u7597\u6210\u529f\u7684\u57fa\u672c\u4fdd\u8bc1\u3002\u7531\u4e8e\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u540e\u7684\u75c5\u7406\u751f\u7406\u6539\u53d8\u6781\u4e3a\u590d\u6742\uff0c\u6709\u591a\u79cd\u56e0\u7d20\u53c2\u4e0e\uff0c\u9664\u4e86\u8111\u7f3a\u8840\u3001\u7f3a\u6c27\u5bf9\u8111\u7ec6\u80de\u9020\u6210\u635f\u5bb3\uff0c\u66f4\u4e25\u91cd\u7684\u635f\u5bb3\u6765\u81ea\u4e8e\u518d\u704c\u6ce8\u635f\u4f24\uff0c\u75c5\u7076\u533a\u5728\u6062\u590d\u8840\u6d41\u8fc7\u7a0b\u4e2d\uff0c\u9499\u79bb\u5b50\u8d85\u8f7d\uff0c\u5927\u91cfNO\u548c\u6c27\u81ea\u7531\u57fa\u4ee5\u53ca\u8102\u8d28\u8fc7\u6c27\u5316\u7269\u7684\u4ea7\u751f\uff0c\u7ec6\u80de\u819c\u53d7\u635f\uff0c\u7ea7\u8054\u53cd\u5e94\u5f62\u6210\u7684\u7011\u5e03\u6548\u5e94\u5bfc\u81f4\u8111\u6c34\u80bf\u3001\u795e\u7ecf\u7ec6\u80de\u6b7b\u4ea1\u3001\u6897\u585e\u9762\u79ef\u589e\u5927\u4ee5\u53ca\u795e\u7ecf\u75c7\u72b6\u7684\u4ea7\u751f\u3002<\/p>\r\n\r\n\r\n\r\n \u56e0\u6b64\u5bf9\u8111\u7f3a\u8840\u4e0d\u80fd\u5355\u7eaf\u5f3a\u8c03\u8840\u6db2\u518d\u704c\u6d41\uff0c\u800c\u5fc5\u987b\u5c3d\u65e9\u5e94\u7528\u6297\u81ea\u7531\u57fa\u836f\u7269\uff0c\u51cf\u8f7b\u8111\u6897\u6b7b\u7684\u7f3a\u8840\u635f\u4f24\uff0c\u6539\u5584\u795e\u7ecf\u529f\u80fd\uff0c\u6545\u9009\u62e9\u9ad8\u6548\u4f4e\u6bd2\u836f\u7269\u53ca\u8054\u5408\u7528\u836f\u6cbb\u7597\u662f\u4eca\u540e\u7684\u53d1\u5c55\u65b9\u5411\u3002<\/p>\r\n\r\n\r\n\r\n \u6839\u636e\u4e2d\u56fd\u6025\u6027\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u8bca\u6cbb\u6307\u53572010\uff0c\u76ee\u524d\u5df2\u6709\u591a\u79cd\u53ef\u4f9b\u9009\u62e9\u7684\u6025\u6027\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u6cbb\u7597\u65b9\u6cd5\uff0c\u5bf9\u7f3a\u8840\u6027\u635f\u4f24\u75c5\u7406\u751f\u7406\u673a\u5236\u4e2d\u7279\u5b9a\u73af\u8282\u8fdb\u884c\u5e72\u9884\uff0c\u8fd1\u5e74\u7814\u7a76\u70ed\u70b9\u4e3a\u6539\u5584\u8111\u8840\u5faa\u73af\u7684\u591a\u79cd\u63aa\u65bd\uff0c\u6eb6\u6813\u6cbb\u7597 \uff08\u5982\u5c3f\u6fc0\u9176\u3001r-tPA\u7b49\uff09\u3001\u6297\u8840\u5c0f\u677f\u805a\u96c6 \uff08\u5982\u963f\u53f8\u5339\u6797\u7b49\uff09\u3001\u6297\u51dd\u6cbb\u7597\uff08\u5982\u809d\u7d20\u7b49\uff09\u3001\u964d\u7ea4\u3001\u4ee5\u53ca\u795e\u7ecf\u4fdd\u62a4\u7b49\u591a\u79cd\u836f\u7269\u3002\u56e0\u6b64\u5728\u6709\u6548\u6cbb\u7597\u65f6\u95f4\u5185\u5e94\u8054\u5408\u5e94\u7528\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u7684\u836f\u7269\uff0c\u5176\u4e2d\u6700\u4e3b\u8981\u7684\u662f\u4e0e\u8111\u795e\u7ecf\u4fdd\u62a4\u836f\u7269\u7684\u8054\u5408\u3002<\/p>\r\n\r\n\r\n\r\n \u6eb6\u6813\u6cbb\u7597\u662f\u76ee\u524d\u6700\u91cd\u8981\u7684\u6062\u590d\u8840\u6d41\u63aa\u65bd\uff0c\u91cd\u7ec4\u7ec4\u7ec7\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff08r-TPA\uff09\u548c\u5c3f\u6fc0\u9176\uff08UK\uff09\u662f\u6211\u56fd\u76ee\u524d\u4f7f\u7528\u7684\u4e3b\u8981\u6eb6\u6813\u836f\u7269\uff0c\u6709\u6548\u62a2\u6551\u534a\u6697\u5e26\u7684\u65f6\u95f4\u7a97\u4e3a4.5\uff5e6\u5c0f\u65f6\uff0c\u5e76\u589e\u52a0\u9885\u5185\u51fa\u8840\u98ce\u9669\uff1b\u8111\u5352\u4e2d\u540e48h\u5185\u53e3\u670d\u6297\u8840\u5c0f\u677f\u805a\u96c6\u836f\u963f\u53f8\u5339\u6797\u80fd\u663e\u8457\u964d\u4f4e\u75c5\u6b7b\u6216\u6b8b\u75be\u7387\uff0c\u51cf\u5c11\u590d\u53d1\uff0c\u4ec5\u8f7b\u5ea6\u589e\u52a0\u9885\u5185\u51fa\u8840\u98ce\u9669\uff1b\u7531\u4e8e\u8111\u6897\u6b7b\u6025\u6027\u671f\u8840\u6d46\u7ea4\u7ef4\u86cb\u767d\u9176\u539f\u548c\u8840\u6db2\u9ecf\u6ede\u5ea6\u589e\u9ad8\uff0c\u86c7\u6bd2\u9176\u5236\u5242\u53ef\u663e\u8457\u964d\u4f4e\u8840\u6d46\u7ea4\u7ef4\u86cb\u767d\u9176\u539f\uff0c\u5e76\u53ef\u8f7b\u5ea6\u6eb6\u6813\uff0c\u6291\u5236\u8840\u6813\u5f62\u6210\uff0c\u56e0\u6b64\u5bf9\u4e0d\u9002\u5408\u6eb6\u6813\u5e76\u7ecf\u4e25\u683c\u7b5b\u9009\u7684\u8111\u6897\u6b7b\u60a3\u8005\uff0c\u7279\u522b\u662f\u9ad8\u7ea4\u7ef4\u86cb\u767d\u8840\u75c7\u8005\uff0c\u53ef\u9009\u62e9\u964d\u7ea4\u6cbb\u7597\uff0c\u4e3b\u8981\u964d\u7ea4\u836f\u7269\u6709\u964d\u7ea4\u9176\uff08Defibrase\uff09\u3001\u5b89\u514b\u6d1b\u9176\uff08Ancrod\uff09\u7b49\u3002<\/p>\r\n\r\n\r\n\r\n 3<\/strong>\u3001\u540c\u7c7b\u836f\u7269\u7684\u7279\u70b9<\/strong><\/p>\r\n\r\n\r\n\r\n \u4e2d\u56fd\u6025\u6027\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u8bca\u6cbb\u6307\u53572010\u8ba4\u4e3a\uff0c\u9488\u5bf9\u6025\u6027\u7f3a\u8840\u6216\u518d\u704c\u6ce8\u540e\u7ec6\u80de\u635f\u4f24\u7684\u795e\u7ecf\u4fdd\u62a4\u836f\u7269\u53ef\u4fdd\u62a4\u8111\u7ec6\u80de\uff0c\u63d0\u9ad8\u5bf9\u7f3a\u8840\u548c\u7f3a\u6c27\u7684\u8010\u53d7\u6027\u3002\u5176\u4e2d\u4f9d\u8fbe\u62c9\u5949\u4e3a\u4f5c\u4e3a\u4e00\u79cd\u81ea\u7531\u57fa\u6e05\u9664\u5242\u80fd\u6539\u5584\u6025\u6027\u8111\u6897\u6b7b\u7684\u529f\u80fd\u7ed3\u5c40\u5e76\u5b89\u5168\uff0c\u63a8\u8350\u610f\u89c1\u662fI\u7ea7\u63a8\u8350\uff0cB\u7ea7\u8bc1\u636e\u3002\uff3b<\/sup>8<\/sup>\uff3d<\/sup><\/p>\r\n\r\n\r\n\r\n \u4f9d\u8fbe\u62c9\u5949\uff08Edaravone\uff0cMCI-186\uff09\uff0c\u5316\u5b66\u540d3-\u7532\u57fa-1-\u82ef\u57fa-\u5421\u5511\u5549-5-\u916e\uff0c\u662f\u4e00\u79cd\u5408\u6210\u7684\u6c27\u81ea\u7531\u57fa\u6e05\u9664\u5242\uff0c\u4e8e2001\u5e74\u5728\u65e5\u672c\u9996\u6b21\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u8111\u6897\u585e\u3002\u672c\u54c1\u80fd\u6291\u5236\u9ec4\u560c\u5464\u6c27\u5316\u9176\u548c\u6b21\u9ec4\u560c\u5464\u6c27\u5316\u9176\u7684\u6d3b\u6027\uff0c\u523a\u6fc0\u524d\u5217\u73af\u7d20\u7684\u751f\u6210\uff0c\u51cf\u5c11\u708e\u75c7\u4ecb\u8d28\u767d\u7ec6\u80de\u4e09\u70ef\u751f\u6210\uff0c\u964d\u4f4e\u7f9f\u81ea\u7531\u57fa\u6d53\u5ea6\uff0c\u7f29\u5c0f\u7f3a\u8840\u534a\u6697\u5e26\u53d1\u5c55\u6210\u6897\u6b7b\u7684\u4f53\u79ef\uff0c\u5e76\u6291\u5236\u8fdf\u53d1\u6027\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002\uff3b<\/sup>9<\/sup>\uff3d\uff3b<\/sup>10<\/sup>\uff3d<\/sup><\/p>\r\n\r\n\r\n\r\n \u5728\u65e5\u672c\u6700\u65b0\u8111\u5352\u4e2d\u6cbb\u7597\u6307\u53572004\u5e74\u201c\u8111\u5352\u4e2d\u6cbb\u7597\u6307\u5bfc\u539f\u5219\u201d\u4e2d\uff0c\u4f9d\u8fbe\u62c9\u5949\u4f5c\u4e3a\u552f\u4e00\u7ecf\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u6709\u6548\uff0c\u5e76\u6839\u636e\u5faa\u8bc1\u533b\u5b66\u7684\u8bc1\u636e\u88ab\u63a8\u8350\u7528\u4e8e\u6025\u6027\u8111\u6897\u585e\u7684\u8111\u795e\u7ecf\u4fdd\u62a4\u5242\uff0c\u4e3a\u8111\u5352\u4e2d\u7684\u6cbb\u7597\u63d0\u4f9b\u4e00\u79cd\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\r\n\r\n\r\n\r\n \u00a0\u00a0\u00a0 \u4f9d\u8fbe\u62c9\u5949\u4f5c\u4e3a\u6c27\u81ea\u7531\u57fa\u6e05\u9664\u5242\uff0c\u8fd8\u7528\u4e8e\u808c\u8089\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7(Amyotrophic lateral sclerosis\uff0cALS)\u6cbb\u7597\uff0c\u539f\u7814\u5382\u5bb6\u7530\u8fb9\u4e09\u83f1\u5236\u836f\u516c\u53f8\u6b63\u8fdb\u884c\u8be5\u9002\u5e94\u75c7\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\r\n\r\n\r\n\r\n 4<\/strong>\u3001\u672c\u54c1\u7684\u7279\u70b9\u3001\u5f00\u53d1\u4f9d\u636e\u548c\u4e34\u5e8a\u610f\u4e49<\/strong><\/p>\r\n\r\n\r\n\r\n 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4.1<\/strong>\u3001\u836f\u5b66\u7279\u70b9<\/strong><\/p>\r\n\r\n\r\n\r\n \u6cf0\u745e\u62c9\u5949\u5408\u6210\u65b9\u6cd5\u7b80\u5355\uff0c\u5de5\u827a\u7a33\u5b9a\uff0c\u6210\u672c\u4f4e\u5ec9\uff0c\u5173\u952e\u4e2d\u95f4\u4f53\u8d28\u91cf\u6807\u51c6\u63a7\u5236\u4e25\u683c\uff0c\u8d28\u91cf\u53ef\u63a7\uff0c\u4e09\u5e9f\u5c11\u4e14\u6613\u5904\u7406\uff0c\u9002\u5b9c\u5de5\u4e1a\u5316\u751f\u4ea7\uff1b\u672c\u54c1\u5448\u7ed3\u6676\u6001\uff0c\u6676\u578b\u7a33\u5b9a\uff0c\u4e0d\u542b\u7ed3\u6676\u6c34\u548c\u7ed3\u6676\u6eb6\u5242\uff1b\u5f71\u54cd\u56e0\u7d20\u8bd5\u9a8c\u3001\u52a0\u901f\u8bd5\u9a8c6\u4e2a\u6708\u53ca\u957f\u671f\u8bd5\u9a8c36\u4e2a\u6708\u8003\u5bdf\u7ed3\u679c\u663e\u793a\u672c\u54c1\u7a33\u5b9a\u6027\u826f\u597d\u3002<\/p>\r\n\r\n\r\n\r\n \u6ce8\u5c04\u7528\u6cf0\u745e\u62c9\u5949\u52a9\u6eb6\u5242\u4e3a\u7cbe\u6c28\u9178\uff0c\u8d4b\u5f62\u5242\u4e3a\u7518\u9732\u9187\u3002\u672c\u54c1\u5f71\u54cd\u56e0\u7d20\u8bd5\u9a8c\u3001\u52a0\u901f\u8bd5\u9a8c6\u4e2a\u6708\u548c\u957f\u671f\u7a33\u5b9a\u602736\u4e2a\u6708\u8bd5\u9a8c\u8003\u5bdf\u7ed3\u679c\u8868\u660e\u672c\u54c1\u7a33\u5b9a\u6027\u826f\u597d\u3002<\/p>\r\n\r\n\r\n\r\n 4.2\u3001\u836f\u7406\u4f5c\u7528\u548c\u4f5c\u7528\u673a\u7406\u7279\u70b9<\/p>\r\n\r\n\r\n\r\n \u6cf0\u745e\u62c9\u5949\u4f5c\u4e3a\u8111\u795e\u7ecf\u4fdd\u62a4\u836f\u4f9d\u8fbe\u62c9\u5949\u7ed3\u6784\u7c7b\u4f3c\u7269\uff0c\u4f5c\u7528\u673a\u7406\u4e00\u81f4\uff0c\u4e3a\u6c27\u81ea\u7531\u57fa\u6e05\u9664\u5242\u3002\u5927\u9f20\u4f53\u5185\u8111\u7f3a\u8840\u6a21\u578b\u8bc1\u5b9e\uff0c\u672c\u54c1\u5355\u6b21\u6216\u8005\u8fde\u7eed\u7ed9\u836f14\u5929\uff0c\u8d77\u6548\u5242\u91cf\u4e3a1.5 mg\/kg\uff0c\u80fd\u663e\u8457\u6539\u5584\u8111\u7f3a\u8840\u5f15\u8d77\u7684\u795e\u7ecf\u7f3a\u9677\u75c7\u72b6\uff0c\u51cf\u5c0f\u8111\u6897\u6b7b\u9762\u79ef\uff0c\u964d\u4f4e\u6b7b\u4ea1\u7387\uff0c\u663e\u8457\u6539\u5584\u611f\u89c9\u8fd0\u52a8\u529f\u80fd\u3001\u7a7a\u95f4\u5b66\u4e60\u8bb0\u5fc6\u969c\u788d\u548c\u8111\u7ec4\u7ec7\u75c5\u7406\u5b66\u635f\u4f24\u3002\u672c\u54c1\u548c\u4f9d\u8fbe\u62c9\u5949\u91cf\u6548\u5173\u7cfb\u8bd5\u9a8c\u8868\u660e\uff0c\u672c\u54c11.5\u30013.0\u30016.0\u548c12.0 mg\/kg\u5242\u91cf\u7ec4\u8111\u6897\u585e\u9762\u79ef\u6291\u5236\u7387\u5206\u522b\u4e3a34.6%\u300144.9%\u300158.9%\u548c62.5%\uff0c\u4f9d\u8fbe\u62c9\u5949\u540c\u6837\u5242\u91cf\u6291\u5236\u7387\u5206\u522b\u4e3a26.1%\u300135.6%\u300145.1%\u548c42.1%\uff0c\u672c\u54c1\u836f\u6548\u5f3a\u5ea6\u660e\u663e\u4f18\u4e8e\u4f9d\u8fbe\u62c9\u5949\u3002\u7ed3\u5408\u4f9d\u8fbe\u62c9\u5949\u6587\u732e\u62a5\u5bfc\uff0c\u5bf9\u4e8eMCAO\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u6a21\u578b\uff0c\u4f9d\u8fbe\u62c9\u59496 mg\/kg\u5df2\u8fbe\u836f\u6548\u5e73\u53f0\u5242\u91cf\uff0c\u5176\u5bf9\u5e94\u7684\u4e34\u5e8a\u5242\u91cf\uff0860 mg\/\u65e5\uff09\u4e5f\u540c\u6837\u8fbe\u5230\u5230\u7597\u6548\u5e73\u53f0\u5242\u91cf\uff08\u4f9d\u8fbe\u62c9\u5949II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6bcf\u6b2110mg\u300130mg\u548c45mg\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u8fde\u7eed14\u5929\uff0c\u4e09\u4e2a\u5242\u91cf\u7684\u4e34\u5e8a\u6539\u5584\u7387\u5206\u522b\u4e3a47\uff05\u300167\uff05\u548c68\uff05\uff09\uff0c\u5176\u52a8\u7269\u836f\u6548\u4e0e\u4e34\u5e8a\u7597\u6548\u6709\u826f\u597d\u7684\u4e00\u81f4\u6027\u3002\u800c\u672c\u54c112 mg\/kg\u624d\u63a5\u8fd1\u836f\u6548\u5e73\u53f0\u5242\u91cf\uff0c\u56e0\u6b64\u672c\u54c1\u5177\u6709\u63d0\u9ad8\u4e34\u5e8a\u7597\u6548\u7684\u7a7a\u95f4\u3002<\/p>\r\n\r\n\r\n\r\n \u8fdc\u671f\u836f\u6548\u5b66\u8bd5\u9a8c\u91c7\u7528MCAO\u65b9\u6cd5\u5236\u5907\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u6a21\u578b\uff0c\u8fde\u7eed\u7528\u836f14\u5929\uff0c\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\u6cf0\u745e\u62c9\u5949\u9ad8\u5242\u91cf\u7ec4\uff086.0 mg\/kg\uff09\u548c\u4e2d\u5242\u91cf\u7ec4\uff083.0 mg\/kg\uff09\u4f53\u91cd\u589e\u957f\u4e0e\u9633\u6027\u5bf9\u7167\u836f\u4f9d\u8fbe\u62c9\u5949\uff086.0 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\u672c\u54c1\u5927\u9f20\u5355\u6b21\u9759\u8109\u6ce8\u5c04\uff0c\u836f\u6548\u5b66\u8d77\u6548\u5242\u91cf1.5 mg\/kg\u5728\u7ed9\u836f30 min\u65f6\u7684\u8840\u6d46\u6d53\u5ea6\u4e3a15.2 \u03bcM\uff0c\u5242\u91cf3.0\u30016.0\u548c12.0 mg\/kg\u5728\u7ed9\u836f1 h\u65f6\u7684\u8840\u6d46\u6d53\u5ea6\u5206\u522b\u4e3a10.6\u300117.7\u548c28.8 \u03bcM\u3002\u63a8\u6d4b\u672c\u54c1\u4e34\u5e8a\u9759\u8109\u7ed9\u836f\u53ef\u7ef4\u6301\u6709\u6548\u7684\u8840\u6d46\u6d53\u5ea6\u3002PK\/PD\u8bd5\u9a8c\u826f\u597d\u7684\u76f8\u5173\u6027\u652f\u6301\u836f\u6548\u968f\u8840\u6d46\u6d53\u5ea6\u589e\u52a0\u800c\u589e\u5f3a\u3002<\/p>\r\n\r\n\r\n\r\n 4.3<\/strong>\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u70b9<\/strong><\/p>\r\n\r\n\r\n\r\n \u4e34\u5e8a\u524d\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u8868\u660e\uff0c\u5355\u6b21\u9759\u6ce8\u6cf0\u745e\u62c9\u5949\u4f53\u5185\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u5448\u7ebf\u6027\uff0c\u591a\u6b21\u7ed9\u836f\u4f53\u5185\u6ca1\u6709\u84c4\u79ef\u3002\u672c\u54c1\u9759\u8109\u6ce8\u5c04\u540e\u53ef\u5e7f\u6cdb\u5206\u5e03\u4e8e\u7ec4\u7ec7\u5305\u62ec\u8111\u7ec4\u7ec7\u3002\u672c\u54c1\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387\u9ad8\uff0c\u5728\u5927\u9f20\u4f53\u5185\u4e3b\u8981\u901a\u8fc7\u4ee3\u8c22\u6d88\u9664\uff0c\u5bf9\u4e3b\u8981CYP450\u9176\u65e0\u6291\u5236\u548c\u8bf1\u5bfc\u4f5c\u7528\uff0c\u4e3b\u8981\u901a\u8fc7\u5c3f\u6db2\u6392\u6cc4\uff0878%\uff09\uff0c\u5176\u6b21\u4e3a\u80c6\u6c41\u6392\u6cc4\uff0822%\uff09\u3002<\/p>\r\n\r\n\r\n\r\n 4.4<\/strong>\u3001\u5b89\u5168\u6027\u7279\u70b9<\/strong><\/p>\r\n\r\n\r\n\r\n \u4e34\u5e8a\u524d\u5b89\u5168\u6027\u8bc4\u4ef7\u7ed3\u679c\u8868\u660e\uff0c\u672c\u54c1\u5927\u9f2028\u5929\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8cNOAEL\u5242\u91cf\u4e3a45 mg\/kg\uff0c\u6bd2\u6027\u5242\u91cf\u4e3a90 mg\/kg\uff0c\u6bd2\u6027\u8868\u73b0\u4ec5\u4e3a\u7ed9\u836f\u7b2c\u56db\u5468\u65f6\u96c4\u6027\u52a8\u7269\u6444\u98df\u91cf\u51cf\u5c11\uff0c\u6062\u590d\u671f\u53ef\u9006\u3002 Beagle\u72ac\u9759\u8109\u6ce8\u5c0428\u5929\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c NOAEL\u5242\u91cf\u4e3a15 mg\/kg\uff0c\u4e2d\u6bd2\u5242\u91cf\u4e3a45 mg\/kg\u3002\u6bd2\u6027\u53cd\u5e94\u90e8\u4f4d\u4e3a\u6d88\u5316\u7cfb\u7edf\u3001\u795e\u7ecf\u7cfb\u7edf\u548c\u553e\u6db2\u5185\u5206\u6ccc\u7cfb\u7edf\uff0c\u6bd2\u6027\u4f5c\u7528\u5747\u4e3a\u529f\u80fd\u6027\uff0c\u4e14\u4f5c\u7528\u53ef\u9006\u3002\u4e34\u5e8a\u4f7f\u7528\u65f6\u5e94\u6ce8\u610f\u836f\u7269\u5bf9\u6d88\u5316\u7cfb\u7edf\u3001\u795e\u7ecf\u7cfb\u7edf\u548c\u553e\u6db2\u5185\u5206\u6ccc\u7cfb\u7edf\u53ef\u80fd\u5b58\u5728\u7684\u4e0d\u826f\u53cd\u5e94\u3002\u56e0\u6b64\u672c\u54c1\u5927\u9f20\u548c\u72ac28\u5929\u91cd\u590d\u7ed9\u836f\u7684\u5b89\u5168\u8303\u56f4\u826f\u597d\uff0c\u6bd2\u6027\u4f5c\u7528\u5747\u4e3a\u529f\u80fd\u6027\u4e14\u53ef\u9006\u3002\u672c\u54c1\u65e0\u6f5c\u5728\u9057\u4f20\u6bd2\u6027\uff0c\u4e0d\u5f71\u54cd\u5927\u9f20\u7684\u751f\u80b2\u529b\uff0c\u5bf9\u80ce\u9f20\u65e0\u81f4\u7578\u4f5c\u7528\u3002\u5b89\u5168\u836f\u7406\u5b66\u8bd5\u9a8c\u672a\u89c1\u5bf9\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4f5c\u7528\uff0c\u5bf9\u5fc3\u8840\u7ba1\u7cfb\u7edf\u5305\u62ecQ-T\u95f4\u671f\u548c\u547c\u5438\u7cfb\u7edf\u6ca1\u6709\u5f71\u54cd\u3002\u72ac28\u5929\u91cd\u590d\u7ed9\u836f\u5fc3\u7535\u56fe\u672a\u89c1Q-T\u95f4\u671f\u6539\u53d8\u3002\u7279\u6b8a\u5b89\u5168\u6027\u8bd5\u9a8c\u88ab\u52a8\u76ae\u80a4\u8fc7\u654f\u548c\u5168\u8eab\u4e3b\u52a8\u8fc7\u654f\u4e3a\u9634\u6027\uff0c\u5bf9\u7ea2\u7ec6\u80de\u65e0\u6eb6\u8840\u548c\u51dd\u805a\u73b0\u8c61\uff0c\u65e0\u8840\u7ba1\u548c\u808c\u8089\u523a\u6fc0\u6027\u3002\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u8bc4\u4ef7\u7ed3\u679c\u63d0\u793a\u672c\u54c1\u5b89\u5168\u7a97\u8f83\u5bbd\uff0c\u4e34\u5e8a\u98ce\u9669\u53ef\u63a7\uff0c\u652f\u6301\u8fdb\u884cI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\r\n\r\n\r\n\r\n \u5927\u9f20\u8d77\u6548\u5242\u91cf1.5 mg\/kg\uff0c\u5927\u9f20\u5b89\u5168\u5242\u91cf45mg\/kg\u3002\u5927\u9f2028\u5929\u7684NOAEL\u5242\u91cf\u5b89\u5168\u8303\u56f4\u4e3a\u836f\u6548\u5b66\u6700\u4f4e\u6709\u6548\u5242\u91cf\u768430\u500d\uff1b\u6309\u7167AUC\u6bd4\uff0c\u6b63\u5e38\u5927\u9f20\u4e3a36.4\u500d\uff0cMCAO\u5927\u9f20\u4e3a32.7\u500d\u3002\u6bd4\u683c\u72ac28\u5929\u7684\u5b89\u5168\u5242\u91cf\u4e3a15mg\/kg\uff0c\u6bd4\u683c\u72ac28\u5929\u7684NOAEL\u5242\u91cf\u5b89\u5168\u8303\u56f4\u4e3a\u836f\u6548\u5b66\u6700\u4f4e\u6709\u6548\u5242\u91cf\u768430\u500d\uff1b\u6309\u7167AUC\u6bd4\u4e3a37.6\u500d\u3002<\/p>\r\n\r\n\r\n\r\n 5<\/strong>\u3001\u7efc\u5408\u5206\u6790<\/strong><\/p>\r\n\r\n\r\n\r\n \u6025\u6027\u8111\u5352\u4e2d\u662f\u4e34\u5e8a\u591a\u53d1\u75c5\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u81f4\u6b7b\u7387\u3001 \u81f4\u6b8b\u7387\uff0c\u5c45\u6240\u6709\u75be\u75c5\u81f4\u6b8b\u7387\u9996\u4f4d\uff0c\u4e25\u91cd\u5371\u5bb3\u4eba\u7c7b\u5065\u5eb7\u3002\u6c27\u81ea\u7531\u57fa\u4ecb\u5bfc\u7684\u81ea\u7531\u57fa\u8fde\u9501\u53cd\u5e94\uff0c\u662f\u6025\u6027\u8111\u6897\u6b7b\u795e\u7ecf\u635f\u4f24\u5c24\u5176\u662f\u8fdf\u53d1\u795e\u7ecf\u5143\u635f\u4f24\u7684\u91cd\u8981\u539f\u56e0\u3002\u56e0\u6b64\u5c3d\u65e9\u5e94\u7528\u6297\u81ea\u7531\u57fa\u836f\u7269\uff0c\u51cf\u8f7b\u8111\u6897\u6b7b\u7684\u7f3a\u8840\u635f\u4f24\uff0c\u6539\u5584\u795e\u7ecf\u529f\u80fd\uff0c\u6545\u9009\u62e9\u9ad8\u6548\u4f4e\u6bd2\u836f\u7269\u53ca\u8054\u5408\u7528\u836f\u6cbb\u7597\u662f\u6025\u6027\u8111\u5352\u4e2d\u6cbb\u7597\u7684\u91cd\u8981\u7b56\u7565\u3002\u4f9d\u8fbe\u62c9\u5949\u4f5c\u4e3a\u552f\u4e00\u7ecf\u5927\u89c4\u6a21\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u6709\u6548,\u5e76\u6839\u636e\u5faa\u8bc1\u533b\u5b66\u7684\u8bc1\u636e\u88ab\u63a8\u8350\u7528\u4e8e\u6025\u6027\u8111\u6897\u585e\u7684\u8111\u795e\u7ecf\u4fdd\u62a4\u5242\uff0c\u4e3a\u8111\u5352\u4e2d\u7684\u6cbb\u7597\u63d0\u4f9b\u4e00\u79cd\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u3002\u4f46\u662f\u4f9d\u8fbe\u62c9\u5949\u7597\u6548\u8f83\u5f31\uff0c\u4e34\u5e8a\u4e0a\u6709\u6548\u7684\u8111\u795e\u7ecf\u4fdd\u62a4\u5242\u54c1\u79cd\u6781\u4e3a\u6709\u9650\uff0c\u6709\u5fc5\u8981\u7814\u7a76\u5f00\u53d1\u5b89\u5168\u3001\u9ad8\u6548\u7684\u65b0\u578b\u8111\u795e\u7ecf\u4fdd\u62a4\u5242\u6ee1\u8db3\u4e34\u5e8a\u6cbb\u7597\u7684\u9700\u8981\u3002\u6cf0\u745e\u62c9\u5949\u4f5c\u4e3a\u4f9d\u8fbe\u62c9\u5949\u7684\u7ed3\u6784\u7c7b\u4f3c\u7269\uff0c\u4f5c\u7528\u673a\u7406\u4e00\u81f4\uff0c\u5177\u6709\u6d88\u9664\u6c27\u81ea\u7531\u57fa\u4f5c\u7528\u66f4\u5f3a\u3001\u5b89\u5168\u6027\u826f\u597d\uff0c\u5177\u6709\u8f83\u597d\u4e34\u5e8a\u5e94\u7528\u7279\u70b9\u7684\u8111\u795e\u7ecf\u4fdd\u62a4\u836f\uff0c\u4e34\u5e8a\u53ef\u7528\u4e8e\u6539\u5584\u6025\u6027\u8111\u6897\u585e\u6240\u81f4\u7684\u795e\u7ecf\u75c7\u72b6\u3001\u65e5\u5e38\u751f\u6d3b\u6d3b\u52a8\u80fd\u529b\u548c\u529f\u80fd\u969c\u788d\u3002<\/p>\r\n\r\n\r\n\r\n \u5927\u9f20\u8d77\u6548\u5242\u91cf1.5 mg\/kg\uff0c\u5927\u9f20\u5b89\u5168\u5242\u91cf45mg\/kg\u3002\u5927\u9f2028\u5929\u7684NOAEL\u5242\u91cf\u5b89\u5168\u8303\u56f4\u4e3a\u836f\u6548\u5b66\u6700\u4f4e\u6709\u6548\u5242\u91cf\u768430\u500d\uff1b\u6309\u7167AUC\u6bd4\uff0c\u6b63\u5e38\u5927\u9f20\u4e3a36.4\u500d\uff0cMCAO\u5927\u9f20\u4e3a32.7\u500d\u3002\u6bd4\u683c\u72ac28\u5929\u7684\u5b89\u5168\u5242\u91cf\u4e3a15mg\/kg\uff0c\u6bd4\u683c\u72ac28\u5929\u7684NOAEL\u5242\u91cf\u5b89\u5168\u8303\u56f4\u4e3a\u836f\u6548\u5b66\u6700\u4f4e\u6709\u6548\u5242\u91cf\u768430\u500d\uff1b\u6309\u7167AUC\u6bd4\u4e3a37.6\u500d\u3002\u6309\u7167\u6700\u5c0f\u6bd430\u500d\u8ba1\u7b97\uff0c\u4eba\u4f53\u7b49\u6548\u5242\u91cf\uff08HED\uff09\u7684\u6700\u5927\u5b89\u5168\u5242\u91cf\uff08MRSD\uff09\u4e3a7.29mg\/kg\u3002\u53d6\u5b89\u5168\u7cfb\u657010\uff0c\u4eba\u4f53\u9996\u5242\u6700\u5927\u5b89\u5168\u63a8\u8350\u8d77\u59cb\u5242\u91cf\uff08MRSD\uff09\u786e\u5b9a\u4e3a0.729 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