{"id":839,"date":"2022-09-20T08:34:48","date_gmt":"2022-09-20T00:34:48","guid":{"rendered":"http:\/\/www.chinrilymedica.cn\/?p=839"},"modified":"2022-10-18T15:04:46","modified_gmt":"2022-10-18T07:04:46","slug":"crm-2102%e5%af%b9%e5%86%88%e7%94%b0%e9%85%b8%e8%af%b1%e5%af%bcsh-sy5y%e7%bb%86%e8%83%9etau%e8%9b%8b%e7%99%bd%e7%a3%b7%e9%85%b8%e5%8c%96%e7%9a%84%e5%bd%b1%e5%93%8d","status":"publish","type":"post","link":"http:\/\/www.chinrilymedica.cn\/?p=839","title":{"rendered":"CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-801\" src=\"http:\/\/www.chinrilymedica.cn\/wp-content\/uploads\/2022\/09\/PDF.jpg\" alt=\"\" width=\"21\" height=\"20\" \/><a href=\"http:\/\/www.chinrilymedica.cn\/wp-content\/uploads\/2022\/09\/CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd.pdf\">CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd<\/a><\/p>\n<p><span class=\"fontstyle0\"><strong>\u76ee\u7684:<\/strong> \u7814\u7a76 <\/span><span class=\"fontstyle2\">CRM-2102 <\/span><span class=\"fontstyle0\">\u5bf9\u5188\u7530\u9178\uff08<\/span><span class=\"fontstyle2\">OA<\/span><span class=\"fontstyle0\">\uff09\u8bf1\u5bfc <\/span><span class=\"fontstyle2\">tau <\/span><span class=\"fontstyle0\">\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd\u3002 <strong>\u65b9\u6cd5:<\/strong> \u4f53\u5916\u57f9\u517b <\/span><span class=\"fontstyle2\">SH-SY5Y <\/span><span class=\"fontstyle0\">\u7ec6\u80de\uff0c\u7528\u4e0d\u540c\u6d53\u5ea6<\/span><span class=\"fontstyle2\">(0.1-10\u03bcmol\/L)<\/span><span class=\"fontstyle0\">\u7684\u542b\u836f\u57f9\u517b\u57fa\u5904\u7406\u7ec6\u80de <\/span><span class=\"fontstyle2\">24 h<\/span><span class=\"fontstyle0\">\uff0c\u518d\u7528 <\/span><span class=\"fontstyle2\">40 nmol\/L OA <\/span><span class=\"fontstyle0\">\u5904\u7406\u7ec6\u80de <\/span><span class=\"fontstyle2\">24 h<\/span><span class=\"fontstyle0\">\uff0c\u6536\u96c6\u7ec6\u80de\uff0c\u91c7\u7528 <\/span><span class=\"fontstyle2\">Western Blot<\/span><span class=\"fontstyle0\">\u6d4b\u5b9a\u5404\u7ec4\u7ec6\u80de <\/span><span class=\"fontstyle2\">p-tau<\/span><span class=\"fontstyle2\">Ser396<\/span><span class=\"fontstyle0\">\u6c34\u5e73\u3002 <strong>\u7ed3\u679c\uff1a<\/strong> \u4e0e\u9634\u6027\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c <\/span><span class=\"fontstyle2\">1<\/span><span class=\"fontstyle0\">\u3001 <\/span><span class=\"fontstyle2\">3<\/span><span class=\"fontstyle0\">\u3001 <\/span><span class=\"fontstyle2\">10 \u03bcmol\/LCRM-2102 <\/span><span class=\"fontstyle0\">\u7ec4\u7ec6\u80de <\/span><span class=\"fontstyle2\">p-tau<\/span><span class=\"fontstyle2\">Ser396<\/span><span class=\"fontstyle0\">\u6c34\u5e73\u663e\u8457\u4e0b\u964d<\/span><span class=\"fontstyle0\">\uff08<\/span><span class=\"fontstyle3\">P&lt;0.05<\/span><span class=\"fontstyle0\">\uff09<\/span><span class=\"fontstyle0\">\uff0c <\/span><span class=\"fontstyle2\">0.1<\/span><span class=\"fontstyle0\">\u3001 <\/span><span class=\"fontstyle2\">0.3 \u03bcM CRM-2102<\/span><span class=\"fontstyle0\">\u7ec4\u7ec6\u80de <\/span><span class=\"fontstyle2\">p-tau<\/span><span class=\"fontstyle2\">Ser396<\/span><span class=\"fontstyle0\">\u6c34\u5e73\u4e0b\u964d\uff0c\u4f46\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff08<\/span><span class=\"fontstyle3\">P&gt;0.05<\/span><span class=\"fontstyle0\">\uff09\u3002 <strong>\u7ed3\u8bba\uff1a<\/strong> <\/span><span class=\"fontstyle2\">1-10 \u03bcmol\/LCRM-2102 <\/span><span class=\"fontstyle0\">\u80fd\u6291\u5236 <\/span><span class=\"fontstyle2\">OA <\/span><span class=\"fontstyle0\">\u8bf1\u5bfc\u7684\u7ec6\u80de <\/span><span class=\"fontstyle2\">tau <\/span><span class=\"fontstyle0\">\u86cb\u767d\u78f7\u9178\u5316\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd \u76ee\u7684: \u7814\u7a76 CRM-2102 \u5bf9\u5188\u7530\u9178 &#8230; <a title=\"CRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd\" class=\"read-more\" href=\"http:\/\/www.chinrilymedica.cn\/?p=839\" aria-label=\"\u7ee7\u7eed\u9605\u8bfbCRM-2102\u5bf9\u5188\u7530\u9178\u8bf1\u5bfcSH-SY5Y\u7ec6\u80detau\u86cb\u767d\u78f7\u9178\u5316\u7684\u5f71\u54cd\">\u9605\u8bfb\u66f4\u591a<\/a><\/p>\n","protected":false},"author":2,"featured_media":753,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"yes","footnotes":""},"categories":[12],"tags":[],"class_list":["post-839","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-exps"],"_links":{"self":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/posts\/839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=839"}],"version-history":[{"count":1,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/posts\/839\/revisions"}],"predecessor-version":[{"id":841,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/posts\/839\/revisions\/841"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=\/wp\/v2\/media\/753"}],"wp:attachment":[{"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=839"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chinrilymedica.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}